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SB 242084 hydrochloride
CAS No. 1049747-87-6
SB 242084 hydrochloride ( SB-242084 hydrochloride )
产品货号. M10240 CAS No. 1049747-87-6
SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥900 | 有现货 |
|
| 5MG | ￥1235 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SB 242084 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.
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产品描述SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes; also displays >100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors; inhibits 5-HT-stimulated phosphatidylinositol hydrolysis with pKb of 9.3 in cell-baed assays; potently inhibits m-chlorophenylpiperazine (mCPP)-induced hypolocomotion in rats, with an ID50 of 0.11 mg/kg i.p., and 2.0 mg/kg p.o.
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同义词SB-242084 hydrochloride
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number1049747-87-6
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分子量467.80
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分子式C21H19ClN4O2 2HCl
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCC1=NC=CC=C1OC(N=C2)=CC=C2NC(N3CCC4=C3C=C(Cl)C(C)=C4)=O.Cl.Cl
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化学全称1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-, hydrochloride (1:2)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bromidge SM, et al. J Med Chem. 1997 Oct 24;40(22):3494-6.
2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.
4. Higgins GA, et al. Br J Pharmacol. 2001 Jun;133(4):459-66.
2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.
4. Higgins GA, et al. Br J Pharmacol. 2001 Jun;133(4):459-66.
产品手册
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